Resting State LFP Phase Waves

Robin Gutzen

2019-05-06

The LFP and Phase Waves

The Local Field Potential - LFP

The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode

lowpass filtered to reduce the influence of spikes (~250Hz)

Linden et al. 2011
Linden et al. 2011

Why study LFP?

LFP as summary of local network dynamics

overcoming under sampling?

LFP as driver of population dynamics

ephatic coupling?

LFP oscillations

beta band: 13-30Hz

beta_lfp

LFP oscillations

interesting properties: phase, amplitude, spindles

beta_lfp_closeup

What is a face wave?

What is phase wave?

spatial and temporal oscillation of LFP phase

Denker et al. 2018
Denker et al. 2018

What we know so far (excerpt)

(Rubino et al. 2006) there are planar phase waves with preferred directions (M1)

(Denker et al. 2018, Rule et al. 2018) types of waves: planar, synchronous, circular, radial, random

(Townsend et al. 2015, Denker et al. 2018) wave type, propagation velocity, beta power, and behavior correlate

(Townsend et al. 2015) there are preferred transitions between wave types

(Huang et al. 2010) different frequencies are dominant for different wave types

(Denker et al. 2011) phase locking of spikes, stronger for unitary events

(Vinck et al. 2019) gamma phase locking is tuned to orientation (V1)

What is the functional role LFP oscillations in neural network dynamics?

can we find similar wave dynamics in other datasets (tasks, areas)?

how to best characterize the wave dynamics?

investigate relationship of beta power to wave properties

investigate relationship of wave properties to behavior/state

are the findings consistent in other frequency bands?

use wave dynamics to calibrate/validate models

what is the LFP relation to spikes (phase locking, location)?

Resting state LFP phase waves

Nikos ‘doing nothing’

Visualization of wave properties

Phase wave planarity

beta power - phase wave planarity

planarity_bpower

beta event

beta power - phase wave planarity

planarity_bpower_corr

beta power - phase wave planarity - state

planarity_bpower_corr_state

beta power - state

beta_state_stats

preferred direction of phase waves

beta_direction

Up next

  • implement and compare methods for wave characterization

  • apply the analysis to V4A data

  • compare wave characteristics to spike pattern

  • use wave characteristic for model validation